The development molecular photoswitches inside living cells has given rise to completely new options to influence processes inside living cells – using a new methodology called optogenetics. To date, optical control of processes as diverse as controlling membrane potentials, cellular signaling, protein translocation, and gene expression have been shown [for review see 2,3].
While a plethora of new possibilities arise from applying this novel technology, for general cell culture-based approaches only basic do-it-yourself solutions have been published so far (see e.g. the seminal paper by Gerhardt et al.*).
- *Gerhardt, K.P. et al., “An open-hardware platform for optogenetics and photobiology”, Scientific Reports | 6:35363 | DOI: 10.1038/srep35363, 2016
- De Mena et al., “Bringing Light to Transcription: The Optogenetics Repertoire”, Frontiers in Genetics 9, article 518, 2018
- Rost et al., “Optogenetic Tools for Subcellular Applications in Neuroscience”, Neuron 96:572-603, 2017
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